Issue 3, 2019
From the journal:

Chemical Science

Comment on Enantioselective total synthesis of (−)-colchicine, (+)-demecolcinone and metacolchicine: determination of the absolute configurations of the latter two alkaloids by B. Chen, X. Liu, Y.-J. Hu, D.-M. Zhang, L. Deng, J. Lu, L. Min, W.-C. Ye and C.-C. Li, Chem. Sci., 2017, 8, 4961–4966

Reinhard W. Hoffmann, ORCID logo *a   Hans-Günther Schmalz, ORCID logo b   Ulrich Koert ORCID logo a  and  Gregory K. Pierens ORCID logo c  

* Corresponding authors

a Fachbereich Chemie der Philipps Universität Marburg, Hans Meerwein Str. 4, D-35032 Marburg, Germany
E-mail: rwho@chemie.uni-marburg.de

b Department of Chemistry, University of Cologne, Greinstrasse 4, D-50939 Koeln, Germany

c The Centre for Advanced Imaging, The University of Queensland, Building 57, Research Road, St. Lucia, Queensland 4072, Australia

Abstract

We note that some features of the NMR spectra deposited for the purported isomeric metacolchicines (Chem. Sci.8, 4961 (2017)) are not compatible with the assignment of those isomers as being atrop-diastereomers. We suggest that there are no such isomeric metacolchicines as reported. The differences in the spectra could rather be a consequence of a (precedented) monomer/dimer equilibrium of metacolchicine in solution.

Graphical abstract: Comment on Enantioselective total synthesis of (−)-colchicine, (+)-demecolcinone and metacolchicine: determination of the absolute configurations of the latter two alkaloids by B. Chen, X. Liu, Y.-J. Hu, D.-M. Zhang, L. Deng, J. Lu, L. Min, W.-C. Ye and C.-C. Li, Chem. Sci., 2017, 8, 4961–4966

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Article information

DOI
https://doi.org/10.1039/C8SC90247J
Article type
Comment
Submitted
15 Aug 2017
Accepted
28 Nov 2018
First published
18 Dec 2018
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2019,10, 943-945

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Comment on Enantioselective total synthesis of (−)-colchicine, (+)-demecolcinone and metacolchicine: determination of the absolute configurations of the latter two alkaloids by B. Chen, X. Liu, Y.-J. Hu, D.-M. Zhang, L. Deng, J. Lu, L. Min, W.-C. Ye and C.-C. Li, Chem. Sci., 2017, 8, 4961–4966

R. W. Hoffmann, H. Schmalz, U. Koert and G. K. Pierens, Chem. Sci., 2019, 10, 943 DOI: 10.1039/C8SC90247J

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