Issue 11, 2019
From the journal:

Chemical Science

Reductive annulations of arylidene malonates with unsaturated electrophiles using photoredox/Lewis acid cooperative catalysis†

Rick C. Betori,a   Benjamin R. McDonalda  and  Karl A. Scheidt ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Center for Molecular Innovation and Drug Discovery, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA
E-mail: Scheidt@northwestern.edu

Abstract

A cooperative Lewis acid/photocatalytic reduction of salicylaldehyde-derived arylidene malonates provides access to a versatile, stabilized radical anion enolate. Using these unusual umpolung operators, we have developed a novel route to access densely functionalized carbo- and heterocycles through a radical annulation addition pathway.

Graphical abstract: Reductive annulations of arylidene malonates with unsaturated electrophiles using photoredox/Lewis acid cooperative catalysis

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DOI
https://doi.org/10.1039/C9SC00302A
Article type
Edge Article
Submitted
18 Jan 2019
Accepted
03 Feb 2019
First published
06 Feb 2019
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2019,10, 3353-3359

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Reductive annulations of arylidene malonates with unsaturated electrophiles using photoredox/Lewis acid cooperative catalysis

R. C. Betori, B. R. McDonald and K. A. Scheidt, Chem. Sci., 2019, 10, 3353 DOI: 10.1039/C9SC00302A

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