Efficient enantioselective insertion of α-diazoesters into the N–H bond of N-sp2-hybridized benzophenone imine was realized by using Rh2(esp)2 and chiral guanidine cooperative catalysis. Both aliphatic and aromatic substituted α-amino esters were obtained in high yields (up to 99%) and good enantioselectivities (up to 95.5 : 4.5 er) under mild reaction conditions.
J. Yang, P. Ruan, W. Yang, X. Feng and X. Liu, Chem. Sci., 2019, 10, 10305 DOI: 10.1039/C9SC03354H
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