Self-constructing giant vesicles for mimicking biomembrane fusion and acting as enzymatic catalysis microreactors

Shengda Liu; Guo An; Jiayun Xu; Xiumei Li; Tingting Wang; Xiaotong Fan; Chunxi Hou; Quan Luo; Junqiu Liu; Yanqiu Han

doi:10.1039/C8TB02875C

Self-constructing giant vesicles for mimicking biomembrane fusion and acting as enzymatic catalysis microreactors†

Shengda Liu,^a Guo An,^a Jiayun Xu,^a Xiumei Li,^a Tingting Wang,^a Xiaotong Fan,^a Chunxi Hou,^a Quan Luo,

^a Junqiu Liu

*^a and Yanqiu Han*^b

Author affiliations

* Corresponding authors

^a State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, China
E-mail: junqiuliu@jlu.edu.cn

^b Department of Neurology, The Second Hospital, Jilin University, Changchun 130041, P. R. China
E-mail: hanyanqiu@jlu.edu.cn

Abstract

Self-constructing giant fused vesicles based on hydrazone-pillar[5]arene (HP5) were formed catalytically in weak acid via the formation of dynamic covalent bonds in water. The HP5 vesicles mimicked the process of biomembrane fusion and acted as biocatalysis microreactors induced by fusion.

Journal of Materials Chemistry B

Self-constructing giant vesicles for mimicking biomembrane fusion and acting as enzymatic catalysis microreactors†

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Self-constructing giant vesicles for mimicking biomembrane fusion and acting as enzymatic catalysis microreactors

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