Issue 9, 2019
From the journal:

Journal of Materials Chemistry B

Supramolecular azasugar clusters based on an amphiphilic fatty-acid-deoxynojirimycin derivative as multivalent glycosidase inhibitors†

Min Li,ab   Ke-Rang Wang, ORCID logo *a   Jian-Xing Yang,a   Ya-Tong Peng,a   Yi-Xuan Liu,a   Hong-Xin Zhangc  and  Xiao-Liu Li*a  

* Corresponding authors

a Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Ministry of Education), Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding 071002, P. R. China
E-mail: kerangwang@hbu.edu.cn, lixl@hbu.edu.cn

b College of Chemistry and Chemical Engineering, Xingtai University, Xingtai 054001, P. R. China

c Medical Comprehensive Experimental Center of Hebei University, Baoding, China

Abstract

A novel supramolecular multivalent glycosidase inhibitor was constructed based on the amphiphilic deoxynojirimycin derivative FA-DNJ. FA-DNJ self-assembled into spherical assemblies with the diameters between 103 nm and 137 nm under different pH values (pH 2–7) and showed a potent glycosidase effect against α-mannosidase with a Ki value of 0.11 μM, an effect that increased approximately 330-fold compared with that of miglitol. In addition, FA-DNJ exhibited a hypoglycaemic effect in mice.

Graphical abstract: Supramolecular azasugar clusters based on an amphiphilic fatty-acid-deoxynojirimycin derivative as multivalent glycosidase inhibitors

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Article information

DOI
https://doi.org/10.1039/C8TB03249A
Article type
Communication
Submitted
11 Dec 2018
Accepted
23 Jan 2019
First published
24 Jan 2019

J. Mater. Chem. B, 2019,7, 1379-1383

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Supramolecular azasugar clusters based on an amphiphilic fatty-acid-deoxynojirimycin derivative as multivalent glycosidase inhibitors

M. Li, K. Wang, J. Yang, Y. Peng, Y. Liu, H. Zhang and X. Li, J. Mater. Chem. B, 2019, 7, 1379 DOI: 10.1039/C8TB03249A

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