Issue 16, 2019

Silver nanoparticle@DNA tetrahedron-based colorimetric detection of HIV-related DNA with cascade strand displacement amplification

Abstract

DNA tetrahedron-modified silver nanoparticles (AgNPs) were achieved via amino-silver chemistry for the first time and were applied as a colorimetric biosensor for detecting HIV-related DNA. Target DNA initiated strand displacement polymerization and nicking endonuclease-aided cycles were involved to link DNA tetrahedron-modified AgNPs, reporting colorimetric responses. This developed method showed excellent specificity and sensitivity. A wide linear range from 1 to 15 000 nM was achieved with a limit of detection of 0.84 nM. Moreover, it was successfully applied to determine DNA in blood serum samples.

Graphical abstract: Silver nanoparticle@DNA tetrahedron-based colorimetric detection of HIV-related DNA with cascade strand displacement amplification

Supplementary files

Article information

Article type
Communication
Submitted
07 Feb 2019
Accepted
05 Mar 2019
First published
06 Mar 2019

J. Mater. Chem. B, 2019,7, 2608-2612

Silver nanoparticle@DNA tetrahedron-based colorimetric detection of HIV-related DNA with cascade strand displacement amplification

X. Ma and P. Miao, J. Mater. Chem. B, 2019, 7, 2608 DOI: 10.1039/C9TB00274J

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