Issue 29, 2019

The preparation of oxidized methylcellulose crosslinked by adipic acid dihydrazide loaded with vitamin C for traumatic brain injury

Abstract

Traumatic brain injury (TBI) is defined as the destruction or degeneration of brain cells due to external force. Free radical generation from the damage site is the major factor that causes post-therapeutic failure in TBI patient. In this study, an oxi-methylcellulose-adipic acid dihydrazide (oxi-MC-ADH) hydrogel was prepared as a vitamin C carrier for TBI in emergency that continuously releases vitamin C at the injured site in the brain. The results show that the oxi-MC-ADH hydrogel exhibits adequate gelation time and good biocompatibility in vitro. Vitamin C incorporated in the oxi-MC-ADH hydrogel (oxi-MC-ADH-VC) initially burst released in the first 6 h to serve as a primary treatment and then extendedly released for the secondary treatment. The analysis of gene expression and reactive oxygen species production was done to demonstrate the neuroprotective effects of the hydrogel. In vivo neurological function assays and behavioral tests show a significant improvement in the outcome in rats with TBI 3 weeks after the oxi-MC-ADH-VC hydrogel injection. This study demonstrates that the oxi-MC-ADH-VC hydrogel has a great potential in the management of TBI.

Graphical abstract: The preparation of oxidized methylcellulose crosslinked by adipic acid dihydrazide loaded with vitamin C for traumatic brain injury

Supplementary files

Article information

Article type
Paper
Submitted
26 Apr 2019
Accepted
21 Jun 2019
First published
12 Jul 2019

J. Mater. Chem. B, 2019,7, 4499-4508

The preparation of oxidized methylcellulose crosslinked by adipic acid dihydrazide loaded with vitamin C for traumatic brain injury

C. Kuan, Y. Lin, C. Chen, C. Yang, C. Chi, C. Li, G. Dong and F. Lin, J. Mater. Chem. B, 2019, 7, 4499 DOI: 10.1039/C9TB00816K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements