Recent advances of BINOL-based sensors for enantioselective fluorescence recognition

Abstract

Enantioselective fluorescent sensors show large potential for fast, real-time, and highly sensitive measurement of the concentration and enantiomeric composition of chiral molecules. Among all of the sensors, BINOL-based sensors have been actively investigated and extensively used to carry out highly enantioselective, sensitive recognition of chiral α-hydroxycarboxylic acids, amino acids, amino acid derivatives, amino alcohols and amines. In this manuscript, the recent progress of chiral BINOL-based sensors for enantioselective fluorescence recognition of different substrates is reviewed and discussed. The structure of BINOL is tuned by introducing various groups or molecules which systematically changed its fluorescence properties and offered potential for rapid assays of chiral organic molecules. From the development of this area, we gain fresh insight into the challenges and chances of BINOL-based sensors.