A novel electrochemiluminescence sensor based on resonance energy transfer from MoS2QDs@g-C3N4 to NH2-SiO2@PTCA for glutathione assay

Abstract

In this work, a solid-state electrochemiluminescence (ECL) sensor based on resonance energy transfer (RET) was proposed using MoS₂QDs@g-C₃N₄ as a donor and NH₂-SiO₂@PTCA as an acceptor. Herein, MoS₂QDs could significantly facilitate the stability and efficiency of the ECL of g-C₃N₄. PTCA provided a large platform to anchor NH₂-SiO₂ nanoparticles. The prepared MoS₂QDs@g-C₃N₄ exhibited good spectral overlap with the UV–vis absorption spectrum of NH₂-SiO₂@PTCA. Based on this, we designed an “off–on” ECL sensing strategy for sensitive and selective detection of glutathione (GSH). Under the best conditions, the linear range of the sensor for GSH detection was from 0.001 to 100 μM with a detection limit of 0.63 nM (S/N = 3). More importantly, GSH in commercial samples can be detected using the proposed sensor, which indicated its superior detection capabilities and potential application value in commercial medicines.