Issue 9, 2020
From the journal:

Biomaterials Science

Highly responsive and rapid hydrogen peroxide-triggered degradation of polycaprolactone nanoparticles†

Peng-Hao Hsu,a   Carina Arboleda,b   Alexandra Stubelius,‡c   Ling-Wei Li,c   Jason Olejniczaka  and  Adah Almutairi ORCID logo *abc  

* Corresponding authors

a Department of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA
E-mail: aalmutairi@ucsd.edu

b Department of NanoEngineering, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA

c Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA

Abstract

We synthesized an oxidation-responsive polycaprolactone (O-PCL) bearing pendant arylboronic esters as H2O2-responsive motifs. H2O2 induces fast depolymerization of O-PCL within days. Nanoparticles formulated from O-PCL disintegrate and release payload in response to concentrations of H2O2 (50 μM) that are relevant to human disease.

Graphical abstract: Highly responsive and rapid hydrogen peroxide-triggered degradation of polycaprolactone nanoparticles

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Article information

DOI
https://doi.org/10.1039/C9BM02019E
Article type
Communication
Submitted
16 Dec 2019
Accepted
02 Mar 2020
First published
03 Apr 2020

Biomater. Sci., 2020,8, 2394-2397

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Highly responsive and rapid hydrogen peroxide-triggered degradation of polycaprolactone nanoparticles

P. Hsu, C. Arboleda, A. Stubelius, L. Li, J. Olejniczak and A. Almutairi, Biomater. Sci., 2020, 8, 2394 DOI: 10.1039/C9BM02019E

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