Potent and selective PTP1B inhibition by a platinum(II) complex: possible implications for a new antitumor strategy

Caixia Yuan; Weirong Wang; Jianwei Wang; Xinhua Li; Yan-Bo Wu; Shaodong Li; Liping Lu; Miaoli Zhu; Shu Xing; Xueqi Fu

doi:10.1039/C9CC06972K

Potent and selective PTP1B inhibition by a platinum(ii) complex: possible implications for a new antitumor strategy†

Caixia Yuan,

^a Weirong Wang,^a Jianwei Wang,^a Xinhua Li,^a Yan-Bo Wu,

^a Shaodong Li,^a Liping Lu,

*^a Miaoli Zhu,

*^a Shu Xing

*^b and Xueqi Fu

^b

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* Corresponding authors

^a Institute of Molecular Science, Key Laboratory of Chemical Biology and Molecular Engineering of the Education Ministry, Shanxi University, Taiyuan, Shanxi 030006, P. R. China
E-mail: luliping@sxu.edu.cn, miaoli@sxu.edu.cn

^b Edmond H. Fischer Signal Transduction Laboratory, College of Life Sciences, Jilin University, Changchun 130023, P. R. China
E-mail: xingshu@jlu.edu.cn

Abstract

Showing anti-proliferation activity against MCF7 cells better than cisplatin, a platinum(II) complex, [PtL(DMSO)Cl], was found to potently and selectively inhibit protein tyrosine phosphatase 1B (PTP1B), a putative target for anticancer agents, suggesting a new possible anticancer strategy based on platinum drugs.

Chemical Communications

Potent and selective PTP1B inhibition by a platinum(ii) complex: possible implications for a new antitumor strategy†

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Potent and selective PTP1B inhibition by a platinum(II) complex: possible implications for a new antitumor strategy

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