A self-assembling amphiphilic dendrimer nanotracer for SPECT imaging

Ling Ding; Zhenbin Lyu; Aura Tintaru; Erik Laurini; Domenico Marson; Beatrice Louis; Ahlem Bouhlel; Laure Balasse; Samantha Fernandez; Philippe Garrigue; Eric Mas; Suzanne Giorgio; Sabrina Pricl; Benjamin Guillet; Ling Peng

doi:10.1039/C9CC07750B

A self-assembling amphiphilic dendrimer nanotracer for SPECT imaging†

Ling Ding,

^ab Zhenbin Lyu,

^a Aura Tintaru,

^c Erik Laurini,^d Domenico Marson,

^d Beatrice Louis,^ef Ahlem Bouhlel,^ef Laure Balasse,^ef Samantha Fernandez,^ef Philippe Garrigue,

^ef Eric Mas,^g Suzanne Giorgio,^a Sabrina Pricl,

^dh Benjamin Guillet^ef and Ling Peng

*^a

Author affiliations

* Corresponding authors

^a Aix Marseille Univ, CNRS, Centre Interdisciplinaire de Nanoscience de Marseille (UMR 7325), Equipe Labellisée Ligue Contre le Cancer, Marseille, France
E-mail: ling.peng@univ-amu.fr

^b Aix Marseille Univ, CNRS, CRMBM, Marseille, France

^c Aix Marseille Univ, CNRS, Institut de Chimie Radicalaire (UMR7273), Marseille, France

^d Molecular Biology and Nanotechnology Laboratory (MolBNL@UniTS), DEA, University of Trieste, Trieste, Italy

^e Aix Marseille Univ, INSERM, INRA, Marseille, France

^f Aix Marseille Univ, CNRS, Centre Européen de Recherche en Imagerie Médicale (CERIMED), Marseille, France

^g Aix Marseille Univ, CNRS, INSERM, Institut Paoli-Calmettes, Centre de Recherche en Cancérologie de Marseille (CRCM), Marseille, France

^h Department of General Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland

Abstract

Bioimaging has revolutionized modern medicine, and nanotechnology can offer further specific and sensitive imaging. We report here an amphiphilic dendrimer able to self-assemble into supramolecular nanomicelles for effective tumor detection using SPECT radioimaging. This highlights the promising potential of supramolecular dendrimer platforms for biomedical imaging.

Chemical Communications

A self-assembling amphiphilic dendrimer nanotracer for SPECT imaging†

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