An enzyme-initiated DNAzyme motor for RNase H activity imaging in living cell

Namin Hu; Yafang Wang; Chang Liu; Manman He; Cunpeng Nie; Juan Zhang; Qiaoqin Yu; Chuan Zhao; Tingting Chen; Xia Chu

doi:10.1039/C9CC08692G

An enzyme-initiated DNAzyme motor for RNase H activity imaging in living cell†

Namin Hu,^a Yafang Wang,^a Chang Liu,^a Manman He,^a Cunpeng Nie,^a Juan Zhang,^a Qiaoqin Yu,^a Chuan Zhao,^a Tingting Chen

*^a and Xia Chu

*^a

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* Corresponding authors

^a Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China
E-mail: chenting1104@hnu.edu.cn, xiachu@hnu.edu.cn
Fax: +86-731-88821916
Tel: +86-731-88821916

Abstract

In this work, we have developed a novel DNAzyme motor initiated by endogenous enzyme for sensitive imaging of intracellular RNase H activity.

Chemical Communications

An enzyme-initiated DNAzyme motor for RNase H activity imaging in living cell†

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An enzyme-initiated DNAzyme motor for RNase H activity imaging in living cell

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