Oxidative damage of guanine to 8-oxoguanine triggers a partial and variable loss of G-quadruplex/hemin DNAzyme activity and provides clues to the mechanistic origins of DNAzyme deactivation, which originates from an interplay between decreased G-quadruplex stability, lower hemin affinity and a modification of the nature of hemin binding sites.
J. Wang, M. Cheng, J. Chen, H. Ju, D. Monchaud, J. Mergny and J. Zhou, Chem. Commun., 2020, 56, 1839 DOI: 10.1039/C9CC09237D
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