Issue 18, 2020
From the journal:

Chemical Communications

Observation of peroxynitrite overproduction in cells during 5-fluorouracil treatment via a ratiometric fluorescent probe†

Ji-Ting Hou, ORCID logo *ab   Bingya Wang,a   Yongru Zhang,c   Beibei Cui,a   Xinhua Cao,a   Man Zhang,d   Yong Ye ORCID logo *c  and  Shan Wang ORCID logo *a  

* Corresponding authors

a College of Chemistry and Chemical Engineering, Xinyang Normal University, Xinyang 464000, P. R. China
E-mail: houjiting2206@163.com, smallcoral@live.cn

b Ministry of Education, Key Laboratory of Hainan Trauma and Disaster Rescue, College of Emergency and Trauma, Hainan Medical University, Haikou 571199, China

c Phosphorus Chemical Engineering Research Center of Henan Province, College of Chemistry, Zhengzhou University, Zhengzhou 450001, P. R. China
E-mail: yeyong03@tsinghua.org.cn

d School of Chemistry and Materials Science, Hubei Engineering University, Xiaogan 432000, P. R. China

Abstract

We describe a colorimetric and fluorescent probe 3a to detect cellular peroxynitrite with high selectivity and sensitivity. 3a was successfully applied in the bioimaging of exogenous and endogenous peroxynitrite in living cells. The up-regulation of peroxynitrite in cancer cells and normal cells during 5-fluorouracil treatment was finally monitored.

Graphical abstract: Observation of peroxynitrite overproduction in cells during 5-fluorouracil treatment via a ratiometric fluorescent probe

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Article information

DOI
https://doi.org/10.1039/C9CC09652C
Article type
Communication
Submitted
12 Dec 2019
Accepted
28 Jan 2020
First published
28 Jan 2020

Chem. Commun., 2020,56, 2759-2762

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Observation of peroxynitrite overproduction in cells during 5-fluorouracil treatment via a ratiometric fluorescent probe

J. Hou, B. Wang, Y. Zhang, B. Cui, X. Cao, M. Zhang, Y. Ye and S. Wang, Chem. Commun., 2020, 56, 2759 DOI: 10.1039/C9CC09652C

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