Issue 18, 2020
From the journal:

Chemical Communications

A BODIPY-based fluorescent sensor for the detection of Pt2+ and Pt drugs†

Fung-Kit Tang,‡a   Jiaqian Zhu,‡b   Fred Ka-Wai Kong, ORCID logo c   Maggie Ng, ORCID logo c   Qingyuan Bian, ORCID logo a   Vivian Wing-Wah Yam, ORCID logo *c   Anfernee Kai-Wing Tse,*d   Yu-Chung Tse*e  and  Ken Cham-Fai Leung ORCID logo *a  

* Corresponding authors

a Department of Chemistry, State Key Laboratory of Environmental and Biological Analysis, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, P. R. China
E-mail: cfleung@hkbu.edu.hk

b Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, P. R. China

c Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, P. R. China
E-mail: wwyam@hku.hk

d Programme of Food Science and Technology, Division of Science and Technology, Beijing Normal University-Hong Kong Baptist University United International College, Zhuhai 519087, P. R. China
E-mail: kaiwingtse@uic.edu.hk

e Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Department of Biology, Southern University of Science and Technology (SUSTech), Shenzhen, P. R. China
E-mail: tseyc@sustech.edu.cn

Abstract

A BODIPY-based fluorescent sensor PS with an NO4S2 podand ligand was studied for the selective detection of Pt2+ over 21 cations as well as selected platinum drugs in aqueous medium. The platinum sensor PS shows 28-fold, 22-fold and 14-fold fluorescence turn-on enhancements to Pt2+, cisplatin and nedaplatin, and was thereby employed to detect platinum drugs in A-549 human lung cancer cells.

Graphical abstract: A BODIPY-based fluorescent sensor for the detection of Pt2+ and Pt drugs

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Article information

DOI
https://doi.org/10.1039/D0CC00027B
Article type
Communication
Submitted
02 Jan 2020
Accepted
29 Jan 2020
First published
29 Jan 2020

Chem. Commun., 2020,56, 2695-2698

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A BODIPY-based fluorescent sensor for the detection of Pt2+ and Pt drugs

F. Tang, J. Zhu, F. K. Kong, M. Ng, Q. Bian, V. W. Yam, A. K. Tse, Y. Tse and K. C. Leung, Chem. Commun., 2020, 56, 2695 DOI: 10.1039/D0CC00027B

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