Stepwise assembly of nanoclusters guided by DNA origami frames with high-throughput

Xiaodong Xin; Lihui Wang; Kaiwei Wang; Lizhi Dai; Hai Cao; Zheng Li; Ye Tian

doi:10.1039/D0CC00274G

Stepwise assembly of nanoclusters guided by DNA origami frames with high-throughput†

Xiaodong Xin,^abc Lihui Wang,^b Kaiwei Wang,^bd Lizhi Dai,^b Hai Cao,

^e Zheng Li*^af and Ye Tian*^bcg

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* Corresponding authors

^a School of Materials Science and Engineering, Xiangtan University, Xiangtan, China
E-mail: lizheng@xtu.edu.cn

^b National Laboratory of Solid State Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, College of Engineering and Applied Sciences, State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, Nanjing, China
E-mail: ytian@nju.edu.cn

^c Shenzhen Research Institute of Nanjing University, Shenzhen, China

^d School of Science, Xi’an Jiaotong University, Xi’an, China

^e State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemical Engineering, Nanjing Tech University, 30 Puzhu South Road, Nanjing 210009, P. R. China

^f School of Physics and Optoelectronic Engineering, Ludong University, Yantai, China

^g Chemistry and Biomedicine Innovation Center, Nanjing University, Nanjing, China

Abstract

We contrive two strategies to assemble well-defined nanoclusters with high-throughput guided by DNA origami frames either by (1) introducing a micro-sized surface to fabricate patchy particles for binding with DNA structures or (2) restricting the assembly process of free nanoparticles and DNA origami frames on the fixed sites. Both the strategies can omit the process of gel purification of the final products.

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Article information

DOI: https://doi.org/10.1039/D0CC00274G
Article type: Communication
Submitted: 11 Jan 2020
Accepted: 21 Mar 2020
First published: 24 Mar 2020

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Chem. Commun., 2020,56, 4918-4921

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Stepwise assembly of nanoclusters guided by DNA origami frames with high-throughput

X. Xin, L. Wang, K. Wang, L. Dai, H. Cao, Z. Li and Y. Tian, Chem. Commun., 2020, 56, 4918 DOI: 10.1039/D0CC00274G

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Chemical Communications

Stepwise assembly of nanoclusters guided by DNA origami frames with high-throughput†

Abstract

Supplementary files

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Stepwise assembly of nanoclusters guided by DNA origami frames with high-throughput

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