A new FRET probe for ratiometric fluorescence detecting mitochondria-localized drug activation and imaging endogenous hydroxyl radicals in zebrafish

Tao Deng; Xiaojuan Wang; Shengjun Wu; Shiyou Hu; Wei Liu; Tongkai Chen; Zhiqiang Yu; Qin Xu; Fang Liu

doi:10.1039/D0CC00382D

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A new FRET probe for ratiometric fluorescence detecting mitochondria-localized drug activation and imaging endogenous hydroxyl radicals in zebrafish†

Tao Deng,‡^a Xiaojuan Wang,‡^a Shengjun Wu,^a Shiyou Hu,^a Wei Liu,^b Tongkai Chen,^b Zhiqiang Yu,

^c Qin Xu*^a and Fang Liu

*^a

Author affiliations

* Corresponding authors

^a Institute of Tropical Medicine and Artemisinin Research Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, China
E-mail: fangliu@gzucm.edu.cn, xuqin@gzucm.edu.cn

^b Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, China

^c School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou, China

Abstract

A new FRET probe has been prepared for ratiometric fluorescence detection of hydroxyl radicals. It has been successfully used for detecting mitochondria-localized drug activation in living cells and imaging endogenous hydroxyl radicals in zebrafish gastrointestinal (GI) tracts under normal culturing conditions.

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Article information

DOI: https://doi.org/10.1039/D0CC00382D
Article type: Communication
Submitted: 16 Jan 2020
Accepted: 09 Mar 2020
First published: 10 Mar 2020

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Chem. Commun., 2020,56, 4432-4435

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A new FRET probe for ratiometric fluorescence detecting mitochondria-localized drug activation and imaging endogenous hydroxyl radicals in zebrafish

T. Deng, X. Wang, S. Wu, S. Hu, W. Liu, T. Chen, Z. Yu, Q. Xu and F. Liu, Chem. Commun., 2020, 56, 4432 DOI: 10.1039/D0CC00382D

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Chemical Communications

A new FRET probe for ratiometric fluorescence detecting mitochondria-localized drug activation and imaging endogenous hydroxyl radicals in zebrafish†

Abstract

Supplementary files

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A new FRET probe for ratiometric fluorescence detecting mitochondria-localized drug activation and imaging endogenous hydroxyl radicals in zebrafish

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