Issue 56, 2020
From the journal:

Chemical Communications

Precise imaging of mitochondria in cancer cells by real-time monitoring of nitroreductase activity with a targetable and activatable fluorescent probe†

Ning Zhu,‡a   Ge Xu,‡a   Rongchen Wang,a   Tianli Zhu,a   Jiahui Tan,b   Xianfeng Gu ORCID logo *b  and  Chunchang Zhao ORCID logo *a  

* Corresponding authors

a Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, P. R. China
E-mail: zhaocchang@ecust.edu.cn

b Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, P. R. China
E-mail: xfgu@fudan.edu.cn

Abstract

An activatable and mitochondrial-targetable fluorescent probe was developed. This designed probe showed ratiometric fluorescence and light-up near-infrared emission responsiveness to nitroreductase, achieving precise imaging of mitochondria in cancer cells by real-time monitoring of nitroreductase activity.

Graphical abstract: Precise imaging of mitochondria in cancer cells by real-time monitoring of nitroreductase activity with a targetable and activatable fluorescent probe

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Article information

DOI
https://doi.org/10.1039/D0CC00494D
Article type
Communication
Submitted
18 Jan 2020
Accepted
23 Jun 2020
First published
23 Jun 2020

Chem. Commun., 2020,56, 7761-7764

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Precise imaging of mitochondria in cancer cells by real-time monitoring of nitroreductase activity with a targetable and activatable fluorescent probe

N. Zhu, G. Xu, R. Wang, T. Zhu, J. Tan, X. Gu and C. Zhao, Chem. Commun., 2020, 56, 7761 DOI: 10.1039/D0CC00494D

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