Issue 63, 2020
From the journal:

Chemical Communications

COSAN-stabilised omega-3 oil-in-water nanoemulsions to prolong lung residence time for poorly water soluble drugs†

Marcos Navascuez, ORCID logo ab   Damien Dupin,*a   Hans-Jürgen Grande,a   Vanessa Gómez-Vallejo,b   Iraida Loinaz, ORCID logo a   Unai Cossíob  and  Jordi Llop ORCID logo *bc  

* Corresponding authors

a CIDETEC, Basque Research and Technology Alliance (BRTA), Parque Científico y Tecnológico de Gipuzkoa, Donostia-San Sebastián 20014, Spain
E-mail: ddupin@cidetec.es

b Radiochemistry and nuclear Imaging Group, CIC biomaGUNE, 20014 San Sebastian, Guipuzcoa, Spain
E-mail: jllop@cicbiomagune.es

c Centro de Investigación Biomédica en Red, Enfermedades Respiratorias - CIBERES, Spain

Abstract

Herein, we report on the capacity of the amphiphilic inorganic anion cobalt bis(dicarbollide) to stabilise oil-in-water nanoemulsions (NEs). The resulting NEs show long term stability in water and high drug-loading capacity, and can prolong the residence time of hydrophobic drugs in the lungs as determined by in vivo positron emission tomography imaging.

Graphical abstract: COSAN-stabilised omega-3 oil-in-water nanoemulsions to prolong lung residence time for poorly water soluble drugs

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Article information

DOI
https://doi.org/10.1039/D0CC00918K
Article type
Communication
Submitted
04 Feb 2020
Accepted
29 Jun 2020
First published
30 Jun 2020

Chem. Commun., 2020,56, 8972-8975

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COSAN-stabilised omega-3 oil-in-water nanoemulsions to prolong lung residence time for poorly water soluble drugs

M. Navascuez, D. Dupin, H. Grande, V. Gómez-Vallejo, I. Loinaz, U. Cossío and J. Llop, Chem. Commun., 2020, 56, 8972 DOI: 10.1039/D0CC00918K

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