A novel approach for rhodium(iii)-catalyzed C–H functionalization of 2,2′-bipyridine derivatives with alkynes: a significant substituent effect

Abstract

We described a novel approach for the C–H functionalization of 2,2′-bipyridine derivatives with alkynes. DFT calculations and experimental data showed a significant substituent effect at the 6-position of 2,2′-bipyridine, which weakened the adjacent N–Rh bond and provided the possibility of subsequent rollover cyclometalation, C–H activation, and functionalization.