Boosting two-photon photodynamic therapy with mitochondria-targeting ruthenium–glucose conjugates

Abstract

Herein, we present a series of dual-targeted ruthenium–glucose conjugates that can function as two-photon absorption (TPA) PDT agents to effectively destroy tumors by preferentially targeting both tumor cells and mitochondria. The in vivo experiments revealed an excellent tumor inhibitory efficiency of the dual-targeted TPA PSs.