Issue 44, 2020

Generic high-capacity protein capture and release by pH control

Abstract

Techniques for immobilization and release of proteins are of general interest but challenging to develop. Here we show a new method for high-capacity (several μg cm−2) immobilization of proteins in polyelectrolyte brushes by multivalent hydrogen bonds. Upon increasing pH, the proteins are fully released with preserved structure and activity.

Graphical abstract: Generic high-capacity protein capture and release by pH control

Supplementary files

Article information

Article type
Communication
Submitted
17 Feb 2020
Accepted
28 Apr 2020
First published
29 Apr 2020
This article is Open Access
Creative Commons BY license

Chem. Commun., 2020,56, 5889-5892

Generic high-capacity protein capture and release by pH control

G. Ferrand-Drake del Castillo, R. L. N. Hailes, Z. Adali-Kaya, T. Robson and A. Dahlin, Chem. Commun., 2020, 56, 5889 DOI: 10.1039/D0CC01250E

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