Visible-light photoswitching of ligand binding mode suggests G-quadruplex DNA as a target for photopharmacology†
Michael P.
O’Hagan, 
a
Javier
Ramos-Soriano,
a
Susanta
Haldar,
ab
Sadiyah
Sheikh,
a
Juan C.
Morales,
c
Adrian J.
Mulholland
ab
and
M. Carmen
Galan
*a
a
Javier
Ramos-Soriano,
a
Susanta
Haldar,
ab
Sadiyah
Sheikh,
a
Juan C.
Morales,
c
Adrian J.
Mulholland
ab
and
M. Carmen
Galan
*a
Abstract
We report the selective targeting of telomeric G4 DNA with a dithienylethene ligand and demonstrate the robust visible-light mediated switching of the G4 ligand binding mode and G-tetrad structure in physiologically-relevant conditions. The toxicity of the ligand to cervical cancer cells is modulated by the photoisomeric state of the ligand, indicating for the first time the potential of G4 to serve as a target for photopharmacological strategies.
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