Cellulose nanocrystals of variable sulfation degrees can sequester specific platelet lysate-derived biomolecules to modulate stem cell response†
Bárbara B.
Mendes, 
ab
Manuel
Gómez-Florit,
ab
Rui M. A.
Domingues,
*ab
Rui L.
Reis
ab
and
Manuela E.
Gomes
*ab
ab
Manuel
Gómez-Florit,
ab
Rui M. A.
Domingues,
*ab
Rui L.
Reis
ab
and
Manuela E.
Gomes
*ab
Abstract
The surface chemistry of cellulose nanocrystals was engineered to show variable sulfation degrees, which was exploited to modulate platelet lysate-derived biomolecule sequestration and presentation. The protein coronas developed on CNC surfaces were characterized and it was demonstrated how they promote different signaling effects on human adipose-derived stem cell behavior.
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