Issue 69, 2020
From the journal:

Chemical Communications

A two-photon responsive naphthyl tagged p-hydroxyphenacyl based drug delivery system: uncaging of anti-cancer drug in the phototherapeutic window with real-time monitoring†

Amit Kumar Singh,a   Moumita Kundu, ORCID logo b   Samrat Roy,c   Biswajit Roy,a   Sk. Sheriff Shah,a   Asha V Nair,a   Bipul Pal,c   Mahitosh Mondalb  and  N. D. Pradeep Singh ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Indian Institute of Technology Kharagpur, 721302 Kharagpur, West Bengal, India
E-mail: ndpradeep@chem.iitkgp.ac.in

b School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur, India

c Department of Physical Sciences, Indian Institute of Science Education and Research, Kolkata, Mohanpur, Nadia 741246, West Bengal, India

Abstract

We report a two-photon responsive drug delivery system (DDS), namely, p-hydroxyphenacyl–naphthalene–chlorambucil (pHP–Naph–Cbl), having a two-photon absorption (TPA) cross-section of ≥20 GM in the phototherapeutic window (700 nm). Our DDS exhibited both AIE and ESIPT phenomena, which were utilized for the real-time monitoring of anti-cancer drug release.

Graphical abstract: A two-photon responsive naphthyl tagged p-hydroxyphenacyl based drug delivery system: uncaging of anti-cancer drug in the phototherapeutic window with real-time monitoring

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Article information

DOI
https://doi.org/10.1039/D0CC01903H
Article type
Communication
Submitted
12 Mar 2020
Accepted
20 Jul 2020
First published
20 Jul 2020

Chem. Commun., 2020,56, 9986-9989

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A two-photon responsive naphthyl tagged p-hydroxyphenacyl based drug delivery system: uncaging of anti-cancer drug in the phototherapeutic window with real-time monitoring

A. K. Singh, M. Kundu, S. Roy, B. Roy, Sk. S. Shah, A. V. Nair, B. Pal, M. Mondal and N. D. P. Singh, Chem. Commun., 2020, 56, 9986 DOI: 10.1039/D0CC01903H

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