Issue 45, 2020

[3+1+1] type cyclization of ClCF2COONa for the assembly of imidazoles and tetrazoles via in situ generated isocyanides

Abstract

A facile synthesis of imidazoles and tetrazoles via [3+1+1] type cyclization of ClCF2COONa is developed. A diverse array of imidazoles and tetrazoles were obtained in decent yields via isocyanide intermediates. Notably, this is the first example of the cycloaddition of in situ generated isocyanides.

Graphical abstract: [3+1+1] type cyclization of ClCF2COONa for the assembly of imidazoles and tetrazoles via in situ generated isocyanides

Supplementary files

Article information

Article type
Communication
Submitted
13 Mar 2020
Accepted
20 Apr 2020
First published
20 Apr 2020

Chem. Commun., 2020,56, 6106-6109

[3+1+1] type cyclization of ClCF2COONa for the assembly of imidazoles and tetrazoles via in situ generated isocyanides

Y. Wang, Y. Zhou and Q. Song, Chem. Commun., 2020, 56, 6106 DOI: 10.1039/D0CC01919D

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