[3+1+1] type cyclization of ClCF2COONa for the assembly of imidazoles and tetrazoles via in situ generated isocyanides†
Abstract
A facile synthesis of imidazoles and tetrazoles via [3+1+1] type cyclization of ClCF2COONa is developed. A diverse array of imidazoles and tetrazoles were obtained in decent yields via isocyanide intermediates. Notably, this is the first example of the cycloaddition of in situ generated isocyanides.