An ambident electrophilicity of phosphinic acid thioesters is disclosed. Unexpected carbon–sulfur bond formation took place in the reaction between phosphinic acid thioesters and benzyl Grignard reagents. The developed method for benzyl sulfides has a wide substrate scope and was applicable for the synthesis of a drug analog.
Y. Nishiyama, T. Hosoya and S. Yoshida, Chem. Commun., 2020, 56, 5771 DOI: 10.1039/D0CC02039G
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