An enantioselective oxa-Piancatelli reaction was established for the first time using a chiral vanadium(V) catalyst. The dual Brønsted and Lewis acid properties of the vanadium catalyst afforded 4-hydroxycyclopent-2-enone derivatives in up to 90% yields and with 93 : 7 enantiomeric ratios, as well as >20 : 1 diastereomeric ratios.
L. Schober, M. Sako, S. Takizawa, H. Gröger and H. Sasai, Chem. Commun., 2020, 56, 10151 DOI: 10.1039/D0CC02621B
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