N,O-Benzamide difluoroboron complexes as near-infrared probes for the detection of β-amyloid and tau fibrils

Yimin Chen; Chang Yuan; Tianxin Xie; Yuying Li; Bin Dai; Kaixiang Zhou; Yi Liang; Jiapei Dai; Hongwei Tan; Mengchao Cui

doi:10.1039/D0CC02820G

N,O-Benzamide difluoroboron complexes as near-infrared probes for the detection of β-amyloid and tau fibrils†

Yimin Chen,^a Chang Yuan,^a Tianxin Xie,^a Yuying Li,^a Bin Dai,

^b Kaixiang Zhou,^a Yi Liang,^b Jiapei Dai,

^c Hongwei Tan

*^a and Mengchao Cui

*^a

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* Corresponding authors

^a Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, P. R. China
E-mail: cmc@bnu.edu.cn, hongwei.tan@bnu.edu.cn

^b State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, People's Republic of China

^c Wuhan Institute for Neuroscience and Neuroengineering, South-Central University for Nationalities, Wuhan 430074, People's Republic of China

Abstract

In this study, a series of organo difluoroboron probes with a BF₂ benzamide moiety was designed, prepared and evaluated. Among them, 2c displayed the best optical and biological properties, and may be used as a useful near-infrared fluorescent probe for the detection of Aβ plaques and neurofibrillary tangles in AD.

Chemical Communications

N,O-Benzamide difluoroboron complexes as near-infrared probes for the detection of β-amyloid and tau fibrils†

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N,O-Benzamide difluoroboron complexes as near-infrared probes for the detection of β-amyloid and tau fibrils

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