Issue 74, 2020
From the journal:

Chemical Communications

Protecting-group-free synthesis of hydroxyesters from amino alcohols†

Guillaume Reynard,a   Eve-Marline Joseph-Valcin ORCID logo a  and  Hélène Lebel ORCID logo *a  

* Corresponding authors

a Department of Chemistry and Centre in Green Chemistry and Catalysis (CGCC), Université de Montréal, Montréal, Qc, Canada
E-mail: helene.lebel@umontreal.ca

Abstract

The synthesis of hydroxyesters from carboxylic acids and unprotected amino alcohols in both continuous flow and batch processes is reported. The formation of a transient diazonium species with a dinitrite reagent is key in this transformation. The reaction conditions are compatible with a variety of functional groups.

Graphical abstract: Protecting-group-free synthesis of hydroxyesters from amino alcohols

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Article information

DOI
https://doi.org/10.1039/D0CC03242E
Article type
Communication
Submitted
05 May 2020
Accepted
10 Aug 2020
First published
10 Aug 2020

Chem. Commun., 2020,56, 10938-10941

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Protecting-group-free synthesis of hydroxyesters from amino alcohols

G. Reynard, E. Joseph-Valcin and H. Lebel, Chem. Commun., 2020, 56, 10938 DOI: 10.1039/D0CC03242E

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