Issue 61, 2020

Single nucleotide variant discrimination by toehold exchange spherical nucleic acids modulated on hierarchical molybdenum disulfide acanthospheres

Abstract

Toehold exchange spherical nucleic acids (TESNA) modulated on molybdenum disulfide (MoS2) acanthospheres were proposed for the discrimination of single nucleotide variants (SNVs). We rationally optimized the probe by making a trade-off between the discrimination factor (DF) and hybridization ratio (χ). The TESNA platform can distinguish SNVs with significantly improved sensitivity and specificity.

Graphical abstract: Single nucleotide variant discrimination by toehold exchange spherical nucleic acids modulated on hierarchical molybdenum disulfide acanthospheres

Supplementary files

Article information

Article type
Communication
Submitted
13 May 2020
Accepted
29 Jun 2020
First published
29 Jun 2020

Chem. Commun., 2020,56, 8599-8602

Single nucleotide variant discrimination by toehold exchange spherical nucleic acids modulated on hierarchical molybdenum disulfide acanthospheres

M. Zhu, Y. Yu, J. Zhu, Y. Zhou, G. Su, H. Zhu, Y. Chen and M. Liu, Chem. Commun., 2020, 56, 8599 DOI: 10.1039/D0CC03425H

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