Issue 60, 2020
From the journal:

Chemical Communications

Mitochondria-localized in situ generation of rhodamine photocage with fluorescence turn-on enabling cancer cell-specific drug delivery triggered by green light†

Amrita Paul,a   Rakesh Mengji, ORCID logo bc   Manoranjan Bera,a   Mamata Ojha,a   Avijit Jana ORCID logo *bcd  and  N. D. Pradeep Singh ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur-721302, West Bengal, India
E-mail: ndpradeep@chem.iitkgp.ac.in

b Department of Applied Biology, CSIR-Indian Institute of Chemical Technology Hyderabad, Uppal Road, Hyderabad 500007, India

c Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology Hyderabad, Uppal Road, Hyderabad 500007, India

d Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India

Abstract

In this work, we have developed a rhodamine dye based water-soluble, mitochondria-indicating photocage, which gets activated in the mitochondria producing a fluorescent signal and on-demand releases the caged anticancer drug, chlorambucil, in the cancer cells selectively upon irradiation of green light.

Graphical abstract: Mitochondria-localized in situ generation of rhodamine photocage with fluorescence turn-on enabling cancer cell-specific drug delivery triggered by green light

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Article information

DOI
https://doi.org/10.1039/D0CC03524F
Article type
Communication
Submitted
17 May 2020
Accepted
18 Jun 2020
First published
18 Jun 2020

Chem. Commun., 2020,56, 8412-8415

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Mitochondria-localized in situ generation of rhodamine photocage with fluorescence turn-on enabling cancer cell-specific drug delivery triggered by green light

A. Paul, R. Mengji, M. Bera, M. Ojha, A. Jana and N. D. P. Singh, Chem. Commun., 2020, 56, 8412 DOI: 10.1039/D0CC03524F

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