Direct visualization of the conformational change of FUS/TLS upon binding to promoter-associated non-coding RNA

Nesreen Hamad; Hiroki Watanabe; Takayuki Uchihashi; Riki Kurokawa; Takashi Nagata; Masato Katahira

doi:10.1039/D0CC03776A

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Direct visualization of the conformational change of FUS/TLS upon binding to promoter-associated non-coding RNA†

Nesreen Hamad,

^ab Hiroki Watanabe,

^c Takayuki Uchihashi,

*^cd Riki Kurokawa,^e Takashi Nagata

^ab and Masato Katahira

*^ab

Author affiliations

* Corresponding authors

^a Institute of Advanced Energy, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan
E-mail: katahira@iae.kyoto-u.ac.jp

^b Graduate School of Energy Science, Kyoto University, Yoshida-hommachi, Sakyo-ku, Kyoto 606-8501, Japan

^c National Institutes of Natural Sciences, Exploratory Research Center on Life and Living Systems, Aichi 444-8787, Japan

^d Department of Physics and Structural Biology Research Centre, Graduate School of Science, Nagoya University, Nagoya 464-8602, Japan
E-mail: uchihast@d.phys.nagoya-u.ac.jp

^e Research Centre of Genomic Medicine, Saitama Medical University, Saitama 350-0495, Japan

Abstract

High-speed AFM revealed the conformational change of fused in sarcoma (FUS) from a compact to an extended structure upon binding of non-coding RNA, which is supposed to allow FUS to bind to CBP/p300 for transcriptional interference. Thus, a mechanistic insight into transcription regulation by FUS and non-coding RNA is provided.

Download options Please wait...

Supplementary files

Article information

DOI: https://doi.org/10.1039/D0CC03776A
Article type: Communication
Submitted: 28 May 2020
Accepted: 03 Jul 2020
First published: 05 Jul 2020

Download Citation

Chem. Commun., 2020,56, 9134-9137

Permissions

Request permissions

Direct visualization of the conformational change of FUS/TLS upon binding to promoter-associated non-coding RNA

N. Hamad, H. Watanabe, T. Uchihashi, R. Kurokawa, T. Nagata and M. Katahira, Chem. Commun., 2020, 56, 9134 DOI: 10.1039/D0CC03776A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications

Direct visualization of the conformational change of FUS/TLS upon binding to promoter-associated non-coding RNA†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Direct visualization of the conformational change of FUS/TLS upon binding to promoter-associated non-coding RNA

Social activity

Search articles by author

Spotlight

Advertisements