Issue 85, 2020
From the journal:

Chemical Communications

A three-dimensional multipedal DNA walker for the ultrasensitive detection of tumor exosomes†

Huizhen Wang,a   Kejing Wan,a   Yue Zhou,b   Xiaoxiao He,*a   Dinggeng He,*a   Hong Cheng,a   Jin Huang,a   Ruichen Jiaa  and  Kemin Wang ORCID logo *a  

* Corresponding authors

a State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Hunan University, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Changsha 410082, China
E-mail: xiaoxiaohe@hnu.edu.cn, hedinggeng@hnu.edu.cn, kmwang@hnu.edu.cn

b Hunan Branch Center, National Tissue Engineering Center of China, Translational Medical Center, Central Laboratory, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China

Abstract

A three-dimensional (3D) multipedal DNA walker triggered by the specific recognition between aptamers and proteins was developed for ultrasensitive tumor exosome sensing. A detection limit of 1 particle μL−1 was obtained with high selectivity. With the advantages of being simple, cost-effective and ultrasensitive, the biosensor offers potential for the early clinical diagnosis of tumors.

Graphical abstract: A three-dimensional multipedal DNA walker for the ultrasensitive detection of tumor exosomes

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Article information

DOI
https://doi.org/10.1039/D0CC04360E
Article type
Communication
Submitted
23 Jun 2020
Accepted
10 Sep 2020
First published
11 Sep 2020

Chem. Commun., 2020,56, 12949-12952

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A three-dimensional multipedal DNA walker for the ultrasensitive detection of tumor exosomes

H. Wang, K. Wan, Y. Zhou, X. He, D. He, H. Cheng, J. Huang, R. Jia and K. Wang, Chem. Commun., 2020, 56, 12949 DOI: 10.1039/D0CC04360E

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