Issue 65, 2020
From the journal:

Chemical Communications

Water-soluble amphiphilic ruthenium(ii) polypyridyl complexes as potential light-activated therapeutic agents†

Sandra Estalayo-Adrián, ORCID logo *ab   Salvador Blasco, ORCID logo a   Sandra A. Bright,c   Gavin J. McManus,c   Guillermo Orellana, ORCID logo d   D. Clive Williams,c   John M. Kelly ORCID logo a  and  Thorfinnur Gunnlaugsson ORCID logo *a  

* Corresponding authors

a School of Chemistry and Trinity Biomedical Sciences Institute (TBSI), Trinity College Dublin, The University of Dublin, Dublin 2, Ireland
E-mail: estalays@tcd.ie, gunnlaut@tcd.ie

b Advanced Materials and BioEngineering Research (AMBER) Centre, Trinity College Dublin, The University of Dublin, Dublin 2, Ireland

c School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute (TBSI), Trinity College Dublin, The University of Dublin, Dublin 2, Ireland

d Department of Organic Chemistry, Faculty of Chemistry, Universidad Complutense de Madrid, E-28040 Madrid, Spain

Abstract

Two water-soluble amphiphilic Ru(II) polypyridyl complexes containing N-1,10-phenanthrolin-5-yldocosanamide and 1,10-phenanthroline (phen) or 1,4,5,8-tetraazaphenanthrene (TAP) as ligands were synthesised and their photophysical and photobiological properties evaluated; both complexes showed a rapid cellular uptake and displayed phototoxicity against HeLa cervical cancer cells.

Graphical abstract: Water-soluble amphiphilic ruthenium(ii) polypyridyl complexes as potential light-activated therapeutic agents

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Article information

DOI
https://doi.org/10.1039/D0CC04397D
Article type
Communication
Submitted
24 Jun 2020
Accepted
08 Jul 2020
First published
08 Jul 2020

Chem. Commun., 2020,56, 9332-9335

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Water-soluble amphiphilic ruthenium(II) polypyridyl complexes as potential light-activated therapeutic agents

S. Estalayo-Adrián, S. Blasco, S. A. Bright, G. J. McManus, G. Orellana, D. C. Williams, J. M. Kelly and T. Gunnlaugsson, Chem. Commun., 2020, 56, 9332 DOI: 10.1039/D0CC04397D

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