Issue 89, 2020
From the journal:

Chemical Communications

Lipid based biocompatible ionic liquids: synthesis, characterization and biocompatibility evaluation†

Shihab Uddin, ORCID logo a   Md. Raihan Chowdhury, ORCID logo a   Rie Wakabayashi, ORCID logo a   Noriho Kamiya, ORCID logo abc   Muhammad Moniruzzaman ORCID logo d  and  Masahiro Goto ORCID logo *abc  

* Corresponding authors

a Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan
E-mail: m-goto@mail.cstm.kyushu-u.ac.jp
Fax: +81-(0)92-802-2810
Tel: +81-(0)92-802-2806

b Advanced Transdermal Drug Delivery System Centre, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan

c Division of Biotechnology, Centre for Future Chemistry, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan

d Chemical Engineering Department, Universiti Teknologi Petronas, 32610 Seri Iskandar, Perak, Malaysia

Abstract

We report a new series of lipid-based biocompatible ionic liquids (LBILs) consisting of the long-chain phosphonium compound 1,2-dimyristoyl-sn-glycero-3-ethyl-phosphatidylcholine as the cation and the long-chain fatty acids stearic acid, oleic acid, or linoleic acid as anions. These materials were found to be completely miscible with many polar and nonpolar organic solvents as well as dispersible in water. These LBILs also exhibited excellent biocompatibility with an artificial three-dimensional human epidermis model.

Graphical abstract: Lipid based biocompatible ionic liquids: synthesis, characterization and biocompatibility evaluation

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Article information

DOI
https://doi.org/10.1039/D0CC04491A
Article type
Communication
Submitted
29 Jun 2020
Accepted
06 Oct 2020
First published
07 Oct 2020

Chem. Commun., 2020,56, 13756-13759

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Lipid based biocompatible ionic liquids: synthesis, characterization and biocompatibility evaluation

S. Uddin, Md. R. Chowdhury, R. Wakabayashi, N. Kamiya, M. Moniruzzaman and M. Goto, Chem. Commun., 2020, 56, 13756 DOI: 10.1039/D0CC04491A

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