Issue 83, 2020
From the journal:

Chemical Communications

Two-photon photodynamic ablation of tumour cells using an RGD peptide-conjugated ruthenium(ii) photosensitiser†

Zizhuo Zhao,‡a   Kangqiang Qiu,‡b   Jiangping Liu,b   Xiaojuan Haoc  and  Jinquan Wang ORCID logo *cd  

* Corresponding authors

a Department of Ultrasound, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510275, China

b MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China

c Manufacturing, Commonwealth Scientific and Industrial Research Organisation (CSIRO), Clayton, Victoria 3168, Australia

d Guangdong Province Key Laboratory of Biotechnology Drug Candidates, Guangdong Pharmaceutical University, Guangzhou 510006, China
E-mail: wangjinquan@gdpu.edu.cn

Abstract

An RGD-peptide conjugated ruthenium(II) complex has been developed, which functions as a two-photon absorption (TPA) photodynamic therapy (PDT) agent for ablating tumours by selectively targeting the mitochondria of integrin αvβ3-rich tumour cells. This approach offers a new and effective design and application for tumour-targeting metallo-anticancer drugs via two-photon PDT.

Graphical abstract: Two-photon photodynamic ablation of tumour cells using an RGD peptide-conjugated ruthenium(ii) photosensitiser

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Article information

DOI
https://doi.org/10.1039/D0CC04943C
Article type
Communication
Submitted
19 Jul 2020
Accepted
08 Sep 2020
First published
09 Sep 2020

Chem. Commun., 2020,56, 12542-12545

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Two-photon photodynamic ablation of tumour cells using an RGD peptide-conjugated ruthenium(II) photosensitiser

Z. Zhao, K. Qiu, J. Liu, X. Hao and J. Wang, Chem. Commun., 2020, 56, 12542 DOI: 10.1039/D0CC04943C

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