We report the efficient and selective Cu(II)-catalysed β-silylation of naturally occurring dehydroalanine (Dha) residues in various ribosomally synthesized and post-translationally modified peptides (RiPPs). The method is also applicable to proteins, as was shown by the modification of a Dha residue that was chemically introduced into Small Ubiquitin-like Modifier (SUMO).
R. H. de Vries and G. Roelfes, Chem. Commun., 2020, 56, 11058 DOI: 10.1039/D0CC05026A
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