Catechols: a new class of carbonic anhydrase inhibitors†
Katia
D'Ambrosio, 
*a
Simone
Carradori,
b
Stefania
Cesa,
c
Claudiu T.
Supuran
d
and
Giuseppina
De Simone
*a
*a
Simone
Carradori,
b
Stefania
Cesa,
c
Claudiu T.
Supuran
d
and
Giuseppina
De Simone
*a
Abstract
To date, catechols have been only poorly investigated as carbonic anhydrase (CA) inhibitors. Here we report the first structural information on the CA inhibition mechanism of these molecules, showing that they adopt a peculiar binding mode to the enzyme active site which involves the zinc-bound water molecule and the “deep water”.
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