Studying the cellular distribution of highly phototoxic platinated metalloporphyrins using isotope labelling

Riccardo Rubbiani; Wenyu Wu; Anu Naik; Michele Larocca; Lukas Schneider; Roxane Padrutt; Vipin Babu; Christiane König; Doris Hinger; Caroline Maake; Stefano Ferrari; Gilles Gasser; Bernhard Spingler

doi:10.1039/D0CC05196A

Studying the cellular distribution of highly phototoxic platinated metalloporphyrins using isotope labelling†

Riccardo Rubbiani,‡^a Wenyu Wu,

‡^a Anu Naik,‡^a Michele Larocca,

^a Lukas Schneider,

^a Roxane Padrutt,

^a Vipin Babu,

^a Christiane König,^b Doris Hinger,^c Caroline Maake,

^c Stefano Ferrari,

^bd Gilles Gasser

^e and Bernhard Spingler

*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, University of Zurich, Zurich CH 8057, Switzerland
E-mail: spingler@chem.uzh.ch

^b Institute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse 190, Zurich CH 8057, Switzerland

^c Institute of Anatomy, University of Zurich, Winterthurerstrasse 190, Zurich CH 8057, Switzerland

^d Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Videnska 1083, Prague, Czech Republic

^e Chimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology, Paris F-75005, France

Abstract

Novel tetraplatinated metalloporphyrin-based photosensitizers (PSs) are reported, which show excellent phototoxic indexes (PIs) up to 5800 against HeLa cells, which is, to the best of our knowledge, the highest value reported for any porphyrin so far. Furthermore, ⁶⁷Zn isotope labelling allowed the determination of the ratio of zinc to platinum inside the cells using ICP-MS.

Chemical Communications

Studying the cellular distribution of highly phototoxic platinated metalloporphyrins using isotope labelling†

Abstract

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Studying the cellular distribution of highly phototoxic platinated metalloporphyrins using isotope labelling

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