One-pot synthesis of template-free hollow anisotropic CaCO3 structures: towards inorganic shape-mimicking drug delivery systems

Abstract

A major obstacle in the introduction of nanoformulated drugs has been the fact that the shape of the drug delivery systems (DDSs) – the most important parameter driven by the nature of viruses and bacteria – remains almost out-of-scope in artificial systems. Here we propose a potential solution for this problem by developing a template-free approach for the formulation of hollow bacteria-like CaCO₃-based pH-sensitive DDSs with controllable anisotropy and click-release behavior.