Issue 94, 2020

Proof-of-principle for two-stage photodynamic therapy: hypoxia triggered release of singlet oxygen

Abstract

We propose to overcome oxygen deficiency and light attenuation problems in photodynamic therapy (PDT), by separating photoexcitation and singlet oxygen delivery of the PDT process into two distinct operations to be carried out sequentially, at different locations. We now demonstrate the viability of this approach, using 2-pyridone derivative which yields a relatively stable endoperoxide. The initial storage endoperoxide obtained is transformed enzymatically into a more labile compound when placed in hypoxic cell cultures, and releases singlet oxygen significantly faster. The potential of this approach in advancing PDT beyond its current limits is exciting.

Graphical abstract: Proof-of-principle for two-stage photodynamic therapy: hypoxia triggered release of singlet oxygen

Supplementary files

Article information

Article type
Communication
Submitted
08 Sep 2020
Accepted
03 Nov 2020
First published
16 Nov 2020
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2020,56, 14793-14796

Proof-of-principle for two-stage photodynamic therapy: hypoxia triggered release of singlet oxygen

S. Ayan, G. Gunaydin, N. Yesilgul-Mehmetcik, M. E. Gedik, O. Seven and E. U. Akkaya, Chem. Commun., 2020, 56, 14793 DOI: 10.1039/D0CC06031C

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