Indirect detection of intermediate in decarboxylation reaction of phenylglyoxylic acid by hyperpolarized 13C NMR

Jiwon Kim; Yaewon Kim; Quy Son Luu; Jihyun Kim; Chang Qi; Christian Hilty; Youngbok Lee

doi:10.1039/D0CC06331B

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Indirect detection of intermediate in decarboxylation reaction of phenylglyoxylic acid by hyperpolarized ¹³C NMR†

Jiwon Kim,‡^a Yaewon Kim,‡^bc Quy Son Luu,^a Jihyun Kim,^b Chang Qi,^b Christian Hilty

*^b and Youngbok Lee*^ad

Author affiliations

* Corresponding authors

^a Department of Bionano Technology, Hanyang University, Ansan 15588, South Korea
E-mail: yblee@hanyang.ac.kr

^b Department of Chemistry, Texas A&M University, 3255 TAMU, College Station, TX 77843, USA
E-mail: chilty@tamu.edu

^c Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA

^d Department of Applied Chemistry, Hanyang University, Ansan 15588, South Korea

Abstract

The decarboxylation reaction of phenylglyoxylic acid with hydrogen peroxide is studied by real-time hyperpolarized carbon-13 nuclear magnetic resonance (¹³C NMR) spectroscopy at room temperature. A non-observable reaction intermediate is identified using blind selective saturation pulses in the expected chemical shift range, thereby revealing information on the reaction mechanism.

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Article information

DOI: https://doi.org/10.1039/D0CC06331B
Article type: Communication
Submitted: 21 Sep 2020
Accepted: 06 Nov 2020
First published: 08 Nov 2020

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Chem. Commun., 2020,56, 15000-15003

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Indirect detection of intermediate in decarboxylation reaction of phenylglyoxylic acid by hyperpolarized ¹³C NMR

J. Kim, Y. Kim, Q. S. Luu, J. Kim, C. Qi, C. Hilty and Y. Lee, Chem. Commun., 2020, 56, 15000 DOI: 10.1039/D0CC06331B

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