Issue 93, 2020
From the journal:

Chemical Communications

A ratiometric fluorescent probe based on AIEgen for detecting HClO in living cells†

Weijie Zhang, ORCID logo ‡ab   He Wang, ORCID logo ‡a   Feng Li,‡a   Yuncong Chen,bc   Ryan T. K. Kwok,b   Yuhua Huang,*a   Jianglei Zhang,*a   Jianquan Hou*a  and  Ben Zhong Tang ORCID logo *bd  

* Corresponding authors

a Department of Urology, First Affiliated Hospital of Soochow University, 188 Shizi RD, Suzhou 215006, China
E-mail: xf192@163.com, zjl3166@yeah.net, sdfyy_hyh@163.com

b Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration & Reconstruction, Institute for Advanced Study, Department of Chemical and Biomedical Engineering, Division of Life Science, State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Kowloon, Hong Kong 999077, China
E-mail: tangbenz@ust.hk

c State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, P. R. China

d State Key Laboratory of Luminescent Materials and Devices, Center for Aggregation-Induced Emission, South China University of Technology, Guangzhou, Guangdong 510640, China

Abstract

A new ratiometric fluorescent probe, namely TPE-RNS, has been developed for detecting intracellular HClO/ClO− in living cells and discriminating cancer cells from normal cells. Based on the ratiometric fluorescence properties conferred by the AIE and DTBET effects, this probe has excellent sensitivity and specificity for the HCIO response.

Graphical abstract: A ratiometric fluorescent probe based on AIEgen for detecting HClO in living cells

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Article information

DOI
https://doi.org/10.1039/D0CC06582J
Article type
Communication
Submitted
04 Oct 2020
Accepted
27 Oct 2020
First published
29 Oct 2020

Chem. Commun., 2020,56, 14613-14616

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A ratiometric fluorescent probe based on AIEgen for detecting HClO in living cells

W. Zhang, H. Wang, F. Li, Y. Chen, R. T. K. Kwok, Y. Huang, J. Zhang, J. Hou and B. Z. Tang, Chem. Commun., 2020, 56, 14613 DOI: 10.1039/D0CC06582J

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