Issue 99, 2020
From the journal:

Chemical Communications

Gold/Lewis acid catalyzed oxidative cyclization involving activation of nitriles†

Ali Wang,a   Xin Xie,a   Chunli Zhanga  and  Yuanhong Liu ORCID logo *a  

* Corresponding authors

a State Key Laboratory of Organometallic Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China
E-mail: yhliu@sioc.ac.cn

Abstract

A gold-catalyzed oxidative cyclization of alkyne–nitriles using water or alcohol as the external nucleophiles has been developed. The catalytic system, featured with gold and Lewis acid dual catalysis, allows a facile synthesis of functionalized isoquinolin-1(2H)-ones and 1-alkoxy-isoquinolines with a wide structural diversity.

Graphical abstract: Gold/Lewis acid catalyzed oxidative cyclization involving activation of nitriles

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Article information

DOI
https://doi.org/10.1039/D0CC06875F
Article type
Communication
Submitted
15 Oct 2020
Accepted
16 Nov 2020
First published
17 Nov 2020

Chem. Commun., 2020,56, 15581-15584

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Gold/Lewis acid catalyzed oxidative cyclization involving activation of nitriles

A. Wang, X. Xie, C. Zhang and Y. Liu, Chem. Commun., 2020, 56, 15581 DOI: 10.1039/D0CC06875F

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