Issue 23, 2020

Active targeting of gold nanoparticles as cancer therapeutics

Abstract

Gold nanoparticles (AuNPs) are of increasing interest for their unique properties and their biocompatability, minimal toxicity, multivalency and size tunability make them exciting drug carriers. The functionalisaton of AuNPs with targeting moieties allows for their selective delivery to cancers, with antibodies, proteins, peptides, aptamers, carbohydrates and small molecules all exploited. Here, we review the recent advances in targeted-AuNPs for the treatment of cancer, with a particular focus on these classes of targeting ligands. We highlight the benefits and potential drawbacks of each ligand class and propose directions in which the field could grow.

Graphical abstract: Active targeting of gold nanoparticles as cancer therapeutics

Article information

Article type
Review Article
Submitted
28 Aug 2020
First published
22 Oct 2020
This article is Open Access
Creative Commons BY-NC license

Chem. Soc. Rev., 2020,49, 8774-8789

Active targeting of gold nanoparticles as cancer therapeutics

Z. R. Goddard, M. J. Marín, D. A. Russell and M. Searcey, Chem. Soc. Rev., 2020, 49, 8774 DOI: 10.1039/D0CS01121E

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