Issue 13, 2020

Aerobic photolysis of methylcobalamin: structural and electronic properties of the Cbl–O–O–CH3 intermediate

Abstract

Photolysis of methylcobalamin (MeCbl) in the presence of molecular oxygen (O2) has been investigated using density functional theory (DFT) and time-dependent DFT (TD-DFT). The key step involves the formation of the Cbl–O–O–CH3 intermediate as a result of triplet O2 insertion in the Co–C bond in the presence of light. Analysis of low-lying excited states shows that the presence of light is only needed to activate the Co–C bond via the formation of the ligand field (LF) state. The insertion of O2, as well as the change in the spin state, takes place in the ground state. The analysis of the structural and electronic properties of the Cbl–O–O–CH3 intermediate is presented and possible decomposition also discussed.

Graphical abstract: Aerobic photolysis of methylcobalamin: structural and electronic properties of the Cbl–O–O–CH3 intermediate

Supplementary files

Article information

Article type
Paper
Submitted
19 Sep 2019
Accepted
25 Feb 2020
First published
26 Feb 2020

Dalton Trans., 2020,49, 4114-4124

Aerobic photolysis of methylcobalamin: structural and electronic properties of the Cbl–O–O–CH3 intermediate

A. P. Ghosh, P. Lodowski, A. Bazarganpour, M. Leks and P. M. Kozlowski, Dalton Trans., 2020, 49, 4114 DOI: 10.1039/C9DT03740C

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