Issue 16, 2020
From the journal:

Dalton Transactions

Combating metastasis of breast cancer cells with a carboplatin analogue containing an all-trans retinoic acid ligand†

Yi Dai,‡ab   Hai Huang, ORCID logo ‡c   Yang Zhu,a   Junjie Cheng,a   Ai-Zong Shen*d  and  Yangzhong Liu ORCID logo *a  

* Corresponding authors

a CAS Key Laboratory of Soft Matter Chemistry, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, China
E-mail: liuyz@ustc.edu.cn

b College of Pharmaceutical Sciences, Anhui Xinhua University, Hefei, Anhui, China

c West China Hospital, Sichuan University, Chengdu, Sichuan, China

d The First Affiliated Hospital of University of Science and Technology of China, Hefei 230001, China

Abstract

Pt-ATRA, a carboplatin analogue containing an all-trans retinoic acid (ATRA) derivative ligand, was synthesized via a click reaction. Upon cellular internalization, Pt-ATRA exhibits a dual function, releasing an active Pt(II) moiety to induce cell apoptosis and ATRA to inhibit tumor metastasis.

Graphical abstract: Combating metastasis of breast cancer cells with a carboplatin analogue containing an all-trans retinoic acid ligand

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Article information

DOI
https://doi.org/10.1039/D0DT00507J
Article type
Communication
Submitted
11 Feb 2020
Accepted
20 Mar 2020
First published
24 Mar 2020

Dalton Trans., 2020,49, 5039-5043

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Combating metastasis of breast cancer cells with a carboplatin analogue containing an all-trans retinoic acid ligand

Y. Dai, H. Huang, Y. Zhu, J. Cheng, A. Shen and Y. Liu, Dalton Trans., 2020, 49, 5039 DOI: 10.1039/D0DT00507J

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