Issue 47, 2020

A cytotoxic nitrido-osmium(vi) complex induces caspase-mediated apoptosis in HepG2 cancer cells

Abstract

The osmium(VI) nitrido complex [OsVI(N)(sap)(py)Cl] is a potential anti-cancer drug with promising in vitro antiproliferative activities toward a panel of cancer cell lines, including cisplatin-resistant cells (IC50 values of 2.8–13.8 μM). This drug targets DNA and changes its conformation via covalent binding and insertion. In vitro studies indicate that the drug induces HepG2 cells G2/M phase arrest, disrupts the mitochondrial membrane potential and causes caspase-mediated apoptosis. Further in vivo studies using HepG2-bearing nude mice reveal that this drug not only shows good antitumor efficacy of inhibiting tumor growth, but also does not show the side effect of weight loss.

Graphical abstract: A cytotoxic nitrido-osmium(vi) complex induces caspase-mediated apoptosis in HepG2 cancer cells

Supplementary files

Article information

Article type
Paper
Submitted
03 Aug 2020
Accepted
13 Oct 2020
First published
16 Oct 2020

Dalton Trans., 2020,49, 17173-17182

A cytotoxic nitrido-osmium(VI) complex induces caspase-mediated apoptosis in HepG2 cancer cells

W. Huang, C. Wang, T. Liu, Z. Li, C. Pan, Y. Chen, X. Lian, W. Man and W. Ni, Dalton Trans., 2020, 49, 17173 DOI: 10.1039/D0DT02715D

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